Lysosomal function under hormonal effect

 

 

 

(Csaba, G., Cserhalmi, M.: Influence of biogenic amines (histamine, serotonin) on the function of the lysosomal enzymes of the Tetrahymena. Acta Protozool. 24, 135-138, 1985)

 

                

Effect on lysosomal phosphatase activity

Group

Nourished +/- s.d.

Starved +/- s.d.

Control

4.3+/-0.51

2.6+/-0.71

Histamine 10-2 M

5.9+/-0.30

3.9+/-0.48

Histamine 10-3 M

5.5+/-0.25

4.0+/-0.55

Histamine 10-7 M

3.8+/-0.50

2.2+/-0.99

Serotonin 10-3 M

2.3+/-0.94

1.2+/-1.17

Chloroquine 2x10-4 M

-

3.1+/-1.01

Chloroquine+histamine 10-3 M

-

2.3+/-0.83

 

Conclusions:

1. Histamine and serotonin which stimulate phagocytosis in Tetrahymena differently act on the  lysosomal phosphatase activity,

2. The lysosomal enzyme inhibitor chloroquine is neutral alone, however depress the activity of histamine.