CH-Table 1

 

Effects of dipeptides containing the amino acid, proline on the chemotaxis of Tetrahymena pyriformis

 

(Kőhidai, L., Soós, P., Csaba, G. Cell Biol. Internat. 21:341-345 1997)

 

 

Dipeptides

Chemotactic

potency

at 10-6 M [%]

Significance

p<

Residual volume (F) of varying amino acids

Lipophilicity of varying amino acids

Gly-Pro

290

0.01

36.1

-3.0

Ala-Pro

262

0.01

53.2

-2.67

Pro-Pro

210

0.01

73.6

-2.62

Leu-Pro

162

0.05

100.1

-1.72

Phe-Pro

100

-

113.9

-1.17

Val-Pro

90

-

83.9

-2.29

Pro-Gly

240

0.01

 

 

Pro-Ala

100

-

 

 

Pro-Leu

222

0.01

 

 

Pro-Val

95

-

 

 

Pro-Phe

133

0.05

 

 

Phe-Pro

100

-

 

 

 

 

Conclusions:

 

  1. Proline-containing dipeptides can provoke a chemosensory response from the unicellular Tetrahymena.
  2. These chemotactic effects have close relationship with the residual volumes of  side chains and lipophilicity of amino acids on the N-terminus.
  3. In respoect of chemoattractant character of the dipeptides tested the small side chain and non-polar amino acids are prefererd on the N-terminus.
  4. On the C-terminus small and large  side chains can induce chemotaxis alike.