Table 7.
Effect
of repeated and long term histamine exposure on the phagocyte coefficient of Tetrahymena
(Csaba, G.,
Lantos, T. An attempt to differentiate selection and amplification in hormone
receptor development, Differentiation, 8, 57-59, 1977).
|
Group |
Days
0 |
4 |
9 |
14 |
21 |
28 |
35 |
|
1.Control |
1.0 |
1.0 |
1.0 |
1.0 |
1.0 |
1.0 |
1.0 |
|
2.Control +
3-min histamine treatment |
1.46* |
1.49* |
1.47* |
1.47* |
1.58* |
1.57* |
1,61* |
|
3.Long-term
histamine treatment |
|
2.32** |
2.45** |
2.58** |
2.45** |
2.50** |
2.60** |
|
4.Return to
normal medium |
|
|
|
|
1.14*** |
1.04 |
1.04 |
|
Return to
normal medium + 3-min histamine treatment |
|
|
|
|
1.91o |
1.75o |
1.68o |
Significances:
(p<0.01) 1-2*; 1-3**; 1-4***; 2-5 (p<0.05) o
Conclusions:
1.
Histamine treatment enhances phagocytosis of
Tetrahymena.
2.
Long term histamine treatment enormously
increases the phagocyte coefficient.
3.
One week after returning to normal medium phagocytosis is significantly higher than
control.
4.
The pretreated Tetrahymena react more intensely to a
new treatment with the same substance.
5.
This means that a hormonal imprinting developed, Tetrahymena memorized the first encounter and this memory is transmitted
to the progeny generations (see also
Csaba, G., Phylogeny and ontogeny of hormone receptors: the selection theory of
receptor formation and hormonal imprinting.
Biol. Rev. 55, 47-63, 1980 ).
6.
This phenomenon could have a role in the evolution of
hormone-receptor system.