CH-Table 1

Effects of dipeptides containing the amino acid, proline on the chemotaxis of Tetrahymena pyriformis

(Kőhidai, L., Soós, P., Csaba, G. Cell Biol. Internat. 21:341-345 1997)

Dipeptides	Chemotactic potency at 10^-6 M [%]	Significance p<	Residual volume (F) of varying amino acids	Lipophilicity of varying amino acids
Gly-Pro	290	0.01	36.1	-3.0
Ala-Pro	262	0.01	53.2	-2.67
Pro-Pro	210	0.01	73.6	-2.62
Leu-Pro	162	0.05	100.1	-1.72
Phe-Pro	100	-	113.9	-1.17
Val-Pro	90	-	83.9	-2.29
Pro-Gly	240	0.01
Pro-Ala	100	-
Pro-Leu	222	0.01
Pro-Val	95	-
Pro-Phe	133	0.05
Phe-Pro	100	-

Conclusions:

1. Proline-containing dipeptides can provoke a chemosensory response from the unicellular Tetrahymena.
2. These chemotactic effects have close relationship with the residual volumes of side chains and lipophilicity of amino acids on the N-terminus.
3. In respoect of chemoattractant character of the dipeptides tested the small side chain and non-polar amino acids are prefererd on the N-terminus.
4. On the C-terminus small and large side chains can induce chemotaxis alike.