CH-Table 3

 

Effect of oxytocin and its analogues on the chemotaxis of Tetrahymena pyriformis

 

(Csaba, G., Kovács, K., Kőhidai, L.  Acta Protozool 39: 345-347, 2000)

 

 

Oxytocin and analogues

Chemoattractant

domain [M]

Peak

[M]

Significance

p<

Chemorepellent domain [M]

Peak

[M]

Significance

p<
Ox 1-9

-

-

-

10-11-10-6

10-8

0.001

Ox Ser4, Ile8

10-12; 10-7

10-7

0.001

-

-

-

Ox Thr4, Gly7

-

-

-

10-11; 10-7

10-11

0.01

Ox 6-9

10-10;10-7 -10-6

10-7

0.001

10-12; 10-8

10-8

0.01

Ox 1-6

10-11-10-10;

10-8-10-6

10-10

0.01

-

-

-

Phe3,Arg8 Vasopressin

 

 

 

 

 

 

 

 

 

Conclusions:

 

  1. Exclusively the two real hormones  - oxytocin 1-9 and arginine vasopressin are consecutively repellent.
  2. Other analogues have neutral, atractant or unbalanced chemotactic effect.

 

Chemotaxis results – in concord results of other experiments e.g. effect on the functioon of contactile vacuole – suppose that the two hormones were diverged in function later, during evolution.