In the last decade our investigations were focused onto problems  described in 'Backgrounds'.

      Two problems were investigated:

    The first was to characterize the physicochemical characteristics of the

    hypothetical optimal chemotactic ligand

   

The second purpose was to gain more information about the

 receptor-ligand interactions

in chemotaxis and to describe the

dynamics of the diverse sets of receptors.

   

This work was completed by some basic experiments on the

intracellular signaling

mechanisms and their role in the tuning process of chemotactic responses.