Chemotaxis Research Group
Department of Genetics, Cell and Immunobiology
Semmelweis University
Nagyvárad tér 4., Budapest, Hungary 1089
News
IBCA 2023
Recent publications (2011-2023):
2023
Kiss LZs, Nyárády BB, Pállinger É, Lux Á, Jermendy ÁL, Csobay‑Novák Cs, Soós ·P, Szelid Zs, Láng O, Kőhidai L, Dinya E, ·Dósa E, Merkely B, Bagyura Zs. Association of growth and diferentiation factor‑15 with coronary artery calcium score and ankle‑brachial index in a middle‑aged and elderly Caucasian population sample free of manifest cardiovascular disease. GeroScience doi: 10.1007/s11357-023-00899-y (2023)
Matyas Cs, Trojnar E, Zhao S, Arif M, Mukhopadhyay P, Kovacs A, Fabian A, Tokodi M, Bagyura Zs, Merkely B, Kohidai L, Lajko E, Takacs A, He Y, Gao B, Paloczi J, Lohoff FW, Haskó Gy, Ding W-X, Pacher P. PCSK9, a promising novel target for age-related cardiovascular dysfunction. JACC Basic to Translation Science (in press)
2022
2021
Bagyura Z, Takács A, Kiss L, Dósa E, Vadas R, Nguyen TD, Soós P, Szelid Zs, Kőhidai L, Merkely B. Level of advanced oxidation protein products is associated with subclinical atherosclerosis. BMC Cardiovasc Disord 22, 5 (2022)
Díaz López E, Ríos Díaz A, Vanegas Calderón O, Lajkó E, Ponte-Sucre A, Kőhidai L. Chemotaxis in Leishmania (Viannia) braziliensis: Evaluation by the two-chamber capillary assay. MethodsX doi:10.1016/j.mex.2021.101223
2019
Hegyesi H, Sándor N, Sáfrány G, Lovas V, Kovács Á, Takács A, Kőhidai L, Turiák L, Kittel Á, Pálóczi K, Bertók L, Buzás EI. Radio-detoxified LPS alters bone marrow-derived extracellular vesicles and endothelial progenitor cells. Stem Cell Res Ther. 10(1):313. DOI: 10.1186/s13287-019-1417-4. /2019/
Lang O, Kohidai L, Kohidai Z, Dobo-Nagy C, Csomo KB, Lajko M, Mozes M, Keki S, Deak G, Tian KV, Gresz V. Cell physiological effects of glass ionomer cements on fibroblast cells. Toxicol In Vitro. DOI: 10.1016/j.tiv.2019.104627. /2019/
Fazekas R, Molnár B, Kőhidai L, Láng O, Molnár E, Gánti B, Michailovits G, Windisch P, Vág J. Blood flow kinetics of a xenogeneic collagen matrix following a vestibuloplasty procedure in the human gingiva - An explorative study. Oral Dis. DOI: 10.1111/odi.13163 /2019/2018
Tziakouri A, Lajkó E and Kőhidai L The phylogenetic background of neurotransmitters in the unicellular organism Tetrahymena pyriformis. Annal. Behav. Neurosci. 1 108-118 DOI:10.18314/abne.v1i1.1229 /2018/.
Lajkó E, Spring S, Hegedüs R, Biri-Kovács B, Ingebrandt S, Mező G, Kőhidai L. Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids. Beilstein J. Org. Chem. 14: 2495–2509 /2018/ Supp mat 1 Supp mat 2
Bárány P, Oláh R, Kovács I, Czuczi T, Szabó CSL, Takács A, Lajkó E, Láng O, Kőhidai L, Schlosser G, Bősze Sz, Mező G, Hudecz F, Csámpai A. Ferrocene-containing impiridone (ONC201) hybrids: synthesis, DFT modelling, in vitro evaluation and structure-activity relationships. Molecules 23:9 pii: E2248. DOI: 10.3390/molecules23092248
Polgár L, Lajkó E, Soós P, Láng O, Manea M, Merkely B, Mező G, Kőhidai L. Drug targeting to decrease cardiotoxicity – Determination of the cytotoxic effect of GnRH-based conjugates containing doxorubicin, daunorubicin and methotrexate on human cardiomyocytes and endothelial cells. Beilstein J. Org. Chem. 14: 1583-1594 /2018/ Supp mat 1 Supp mat 2
Polgár L, Soós P, Lajkó E, Láng O, Merkely B, Kőhidai L. Platelet impedance adhesiometry - A novel technique for the measurement of platelet adhesion and spreading. Int. J. Lab. Hemat. 40: 372-381 /2018/ DOI: 10.1111/ijlh.12799.
2017
2015 - 2016
2014
Kuo CH, Láng J, Láng O, Kőhidai L, Sivaniah E. The facile generation of two-dimensional stiffness maps in durotactic cell platforms through thickness projections of three-dimensional submerged topography. Methods Cell Biol. 121:49-60 /2014/
2013
2012
2011
Book chapters:
Kőhidai, L. DIE HOMING, DIE GEZIELTE MIGRATION VON IMMUNZELLEN. EXTRAVASATION IN ENTZÜNDUNGEN. Immunologie Seminare. Ed. Pap, E.; Semmelweis Universität, Budapest; pp. 148-162 (2012) ISBN 978-963-9129-83-2Kőhidai, L. AZ IMMUNSEJTEK MIGRÁCIÓJA, HOMING ÉS GYULLADÁSOS EXTRAVAZÁCIÓ. In: Immunológiai szemináriumok. Ed. Fülöp, K.;Semmelweis Egyetem, Budapest; pp. 130-148 (2012) ISBN 978-963-9129-81-8
Recent oral presentations:
Kőhidai L, Lajkó E, Dókus L, Láng O, Jernei T, Takács A, Bárány P, Enyedi KN, Németh Zs, Csámpai A, Pállinger É, Mező G. Impedance-based analysis as a dedicated technique to characterize efficacy of novel antitumour compounds. (4th Conference on Impedance-Based Cellular Assays - IBCA2018, Edinburgh, 2018)
Khorulsuren Z, Lang O, Pallinger E, Foldes A, Horváti K, Mezo G, Vag J, Kohidai L. Effects of novel synthetic polypeptides containing ‘cycloRGD’ sequences – on PDLSC functional characterization. (Chemotaxis Workshop 2017, Budapest, 2017)
Khorolsuren, Z., Lang, O., Pallinger, E., Foldes, A., Horváti, K., Mezo, G., Vag, J., Kohidai, L Effects of novel synthetic polypeptides containing ‘cycloRGD’ sequences - on PDLSC functional characterization. (PhD Scientific Meeting 2017, Budapest, 2017)
Láng, O., Kőhidai, L. Impedimetric characterisation of cell physiological responses in oral biology. (3rd Conference on Impedance-Based Cellular Assays, Regensburg, 2016)
Lajkó, E., Spring, S., Láng, O., Ingebrandt, S., Mező, G., Kőhidai, L. Impedance-based analysis and holographic phase imaging of the GnRH-III-based drug-targeting in melanoma cells. (3rd Conference on Impedance-Based Cellular Assays, Regensburg, 2016)
Biri, B., Vadászi, H., Kiss, B., Ligeti, Z., Csikós, Gy., Lajkó, E., Láng, O., Kőhidai, L., Nyitray, L. Effect of extracellular S100A4 on cell adhesion and migration of epithelial carcinoma cells. (Molecules of Life, FEBS3+ Meeting, Portoroz, 2015)
Kőhidai, L. Chemotaxome - A new member with complex biological entities in systems biology.(158th iCeMS Seminar - iCeMS - Kyoto University, Kyoto, 2014)
Kőhidai, L. Chemotaxome – A new member with complex biological entities in
systems biology. (BSS Formal Seminar, Cavendish Laboratory, University of
Cambridge, 2013.)
Kőhidai, L. ECIS Migration (ECIS Tutorial on Impedance-Based
Cellular Assays, Budapest, 2013.)
Kőhidai, L., Láng, O., Lajkó, E., Láng, J., Polgár, L., Mező,
G. Impedimetry assays – Dedicated ways to evaluate migratory behavior of cells
(2nd Conference on Impedance-Based Cellular Assays - IBCA2013, Budapest, 2013.)
Láng, O., Nagy, K., Láng, J., Perczel-Kovách, K., Varga, G.,
Kőhidai, L. Monitoring dental stem cells on self-assembling peptide hydrogel
scaffold by impedance based techniques. (2nd Conference on Impedance-Based
Cellular Assays - IBCA2013, Budapest, 2013.)
Lajkó, E., Bányai, P., Zámbó, Zs., Szőke, É., Kőhidai, L.
Natural cancer therapeutics – The effects of anthraquinones derived from Rubia
tinctorum L. on melanoma cell lines. (2nd Conference on Impedance-Based Cellular
Assays - IBCA2013, Budapest, 2013.)
Kosztin, A., Polgár, L., Kőhidai, L., Földes, G. Angiogenic
effect of human pluripotent stem cell-derived endothelial cells. (2nd Conference
on Impedance-Based Cellular Assays - IBCA2013, Budapest, 2013.)
Polgár, L., Soós, P., Lajkó, E., Láng, O., Merkely, B.,
Kőhidai, L. Measurement of platelet function with impedimetry - The effect of
agonists and heparin on adhesion and spreading of human platelets. (2nd
Conference on Impedance-Based Cellular Assays - IBCA2013, Budapest, 2013.
Kőhidai, L., Lajkó, E, Láng, J., Láng, O., Vizi, T., Csaba, G., Pállinger, É. Apoptotic and anti-apoptotic effects of prenatal drugs in BeWo human trophoblast cells. (xCELLigence System - Global User Conference 2012, Stockholm, 2012.)
Recent poster presentations:
Lajkó, E., Magyar, K., Kőhidai, L. Real-time monitoring the endothelial reaction induced by R-deprenyl using holographic microscopy and impedance-based method. (Microscopy Conference 2017, Lausanne, Switzerland, 2017)
Giammarresi M, Díaz E, Vanegas O, Kőhidai L, Padrón Nieves M,
Ponte-Sucre A. Role of CGRP1 , NK1 and VPAC receptors on chemotactic responses
induces by putative ligands in vitro on promastigotes of Leishmania (Viannia)
braziliensis. (Chemotaxis Workshop 2017, Budapest, 2017)
Takács,
A., Lajkó, E., Istenes, I., Kőhidai, L., Láng, O. Study of the apoptotic and
cell cycle modulator effects of bortezomib in combination with antioxidants in
melanoma and myeloma cell lines. (Chemotaxis Workshop 2017, Budapest, 2017)
Lajkó,
E., Magyar, K., Kőhidai, L. Impedimetric and holographic microscopic
measurements on endothelial cell reactions induced by R-deprenyl. (Chemotaxis
Workshop 2017, Budapest, 2017)
Khorolsuren, Z., Lang, O., Pallinger, E., Foldes, A., Vag, J., Kohidai, L.
Functional characterization of PDLSC maintained on synthetic peptide coated
surface. (Hungarian Molecular Life Sciences Conference 2017, Eger, 2017)
Krausz,
M., Kovács, ÁF., Kőhidai, L., Pállinger, É., Láng, O. Physiological effects of
melanoma derived extracellular vesicles on immune cells. (Hungarian Molecular
Life Sciences Conference 2017, Eger, 2017)
Kőhidai,
L., Hamada, M., Tziakouri, A., Lajkó, E., Horváti, K., Mező, G., Muto, Y., Láng,
O. Molecular evolution of CCL2 chemokines – Chemotactic ability of 47R, 72K and
89H pentapeptide libraries of MCP-1 in Tetrahymena. (Hungarian Molecular Life
Sciences Conference 2017, Eger, 2017)
Lang,
O., Debrei, D., Kőhidai, Zs., Mező, G, Kőhidai, L. Screening of tuftsin based
oligopeptide library on model cells of oral cavity. (Hungarian Molecular Life
Sciences Conference 2017, Eger, 2017)
Lajkó,
E., Magyar, K., Kőhidai, L. Study of the effect of R-deprenyl on endothelial
function by impedimetry and holographic phase imaging. (Hungarian Molecular Life
Sciences Conference 2017, Eger, 2017)
Lajkó,
E., Law, J.K-Y., Spring, S., Hempel, F., Láng, O., Mező, G., Ingebrandt, S.,
Kőhidai, L. Monitoring the tumor selective effects of GnRH-drug conjugates with
FET- and MEA-based methods. (Hungarian Molecular Life Sciences Conference 2017,
Eger, 2017)
Takács,
A., Lajkó, E., Istenes, I., Kőhidai, L., Láng, O. The molecular background of
the effectiveness of bortezomib in combination with antioxidants in melanoma and
myeloma cell lines. (Hungarian Molecular Life Sciences Conference 2017, Eger,
2017)
Takács,
A., Lajkó, E., Istenes, I., Kőhidai, L., Láng, O. Comparative study on the
effectiveness of bortezomib in combination with alpha lipoic acid and thiamine
in melanoma and myeloma cell lines. (3rd Conference on Impedance-Based Cellular
Assays, Regensburg, 2016)
Lajkó,
E., Spring, S., Láng, O., Ingebrandt, S., Mező, G., Kőhidai, L. Impedance-based
analysis and holographic phase imaging of the GnRH-III-based drug-targeting in
melanoma cells. (3rd Conference on Impedance-Based Cellular Assays, Regensburg,
2016)
Kovács,
Á.F., Láng, O., Kőhidai, L., Rigó, L., Fekete, N., Buzás, E.I., Pállinger, É.
Impact of preeclampsia-associated extracellular vesicles on the
monocyte-macrophage system: an in vitro analysis. (ISEV 2016 Annual Meeting,
Rotterdam, 2016)
Láng,
O., Láng, J., Sivaniah, E., Kőhidai, L. Mechanopharmacological screening
platform. (Hungarian Molecular Life Sciences Conference 2015, Eger, Hungary,
2015)
Láng,
O., Kőhidai, Zs., Nagy, K., Láng, J., Nagy, K., Perczel-Kovách, K., Lohinai, Zs.,
Varga, G., Kőhidai, L. Biological effect of mouthwash compounds on dental stem
cells and gingival epithelium. (Hungarian Molecular Life Sciences Conference
2015, Eger, Hungary, 2015)
Biri,
B., Kiss, B., Király, R., Schlosser, G., Láng, O., Kőhidai, L., Fésüs, L.,
Nyitray, L. Metastasis-associated S100A4 serves as a specific amine substrate
for tissue transglutaminase-2. (Hungarian Molecular Life Sciences Conference
2015, Eger, Hungary, 2015)
Kosztin,
A., Polgár, L., Kőhidai, L., Várnai, P., Gara, E., Skopál, J., Harding, S.,
Merkely, B., Földes, G. Angiogenic and positive inotropic effects of apelin
fragments on human pluripotein stem cell-derived cardivascular cells.
(FEPS-2014, Budapest, 2014)
Lajkó,
E., Mércz, K., Polgár, L., Manea, M., Szabó, I., Pállinger, É., Mező, G.,
Kőhidai, L. Investigations on the prospective use of GnRH-III based conjugates
for targeted chemotherapy as drug delivery systems in different tumor cells.
(The 11th International Symposium on GnRH, Salzburg, Austria, 2014)
Enyedi,
K.N., Kőhidai, L., Lajkó, E., Mező, G. Targeting cancer-associated fibroblast by
their tumor specific receptors. (EU COST, Chemical Approaches to Targeting Drug
Resistance in Cancer Stem Cells - 2nd Working Group Meeting, Budapest, Hungary,
2014)
Giammarresi, M., Vanegas, O., Díaz, E., Köhidai, L., Padrón M., Ponte-Sucre, A.
Papel de los receptores NK1 en la respuesta quimiotáctica inducida in vitro por
SP en promastigotes de Leishmania (Viannia) braziliensis. (V Jornadas del
Postgrado de Farmacología, (sin libro de resúmenes), Universidad Central de
Venezuela, Caracas, 2014.)
Giammarresi, M., Vanegas, O., Díaz, E., Köhidai, L., Padrón M., Ponte-Sucre, A.
Papel de los receptores NK1 en la respuesta quimiotáctica inducida in vitro por
SP en promastigotes de Leishmania (Viannia) braziliensis. (LXV Convención Anual
de AsoVAC. Caracas, Venezuela, 2014.)
Lajkó,
E., Bányai, P., Zámbó, Zs., Szőke, É., Kőhidai, L. Natural cancer therapeutics –
The effects of anthraquinones derived from Rubia tinctorum L. on melanoma cell
lines. (2nd Conference on Impedance-Based Cellular Assays - IBCA2013, Budapest,
2013.)
Kosztin, A., Polgár, L., Kőhidai, L., Földes, G. Angiogenic
effect of human pluripotent stem cell-derived endothelial cells. (2nd Conference
on Impedance-Based Cellular Assays - IBCA2013, Budapest, 2013.)
Polgár, L., Soós, P., Lajkó, E., Láng, O., Merkely, B.,
Kőhidai, L. Measurement of platelet function with impedimetry - The effect of
agonists and heparin on adhesion and spreading of human platelets. (2nd
Conference on Impedance-Based Cellular Assays - IBCA2013, Budapest, 2013.)
Biri, B., Láng, O., Méhes, E., Czirók, A., Kőhidai, L.,
Nyitray, L. Motility and adhesion assays related to the effect of
metastasis-associated S100A4 protein. (2nd Conference on Impedance-Based
Cellular Assays - IBCA2013, Budapest, 2013.)
Láng, J., Kuo, R., Láng, O., Kőhidai, L., Sivaniah, E. Study
of the interdependence of cell adhesion migration and mechanosensing using a
complex, innovative approach. (2nd Conference on Impedance-Based Cellular Assays
- IBCA2013, Budapest, 2013.)
Slezák, S., Lajkó, E., Pállinger, É., Bai, K.B., Mező, G.,
Gera, I., Kőhidai, L. Monitoring of the effect of oligotuftsin derivatives on
the adhesion of crevicular fluid cells. (2nd Conference on Impedance-Based
Cellular Assays - IBCA2013, Budapest, 2013.)
Lajkó, E., Mércz, K., Manea, M., Mező, G., Kőhidai, L.,
Pállinger, É. Cell adhesion and proliferation of BeWo choriocarcinoma cell line
induced by GnRH-III based targeted systems. (2nd Conference on Impedance-Based
Cellular Assays - IBCA2013, Budapest, 2013.)
Bäcker, H., Polgár, L., Soós, P., Lajkó, E., Láng, O.,
Weymann, A., Szabó, G., Kőhidai, L. Effect of heart scaffold ECM proteins on
cell adhesion of cardiac myocytes - Model experiments of cell adhesion based
loading of porcine heart scaffold. (2nd Conference on Impedance-Based Cellular
Assays - IBCA2013, Budapest, 2013.)
Lajkó, E., Polgár, L., Leurs, U., Manea, M., Szabó, I., Mező, G., Kőhidai, L. Significance of cell adhesion and chemotaxis in therapeutic targeting of tumor cell lines by cytotoxic GnRH-III conjugates. (xCELLigence System - Global User Conference 2012, Stockholm, 2012.)
Polgár, L., Soós, P., Lajkó, E., Láng, O., Merkely, B.,
Kőhidai, L. Impedimetry – Novel method for measurement of platelet adhesion. (xCELLigence
System - Global User Conference 2012, Stockholm, 2012.)
Last update 2023.08.09.
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